Not automatically. Substantive office actions are common; in the US, roughly half of all applications receive one; and many are successfully resolved. The key is understanding what the examiner has raised and whether there are realistic arguments to address it.
Read the office action carefully. The examiner will identify the specific mark that is cited (in a likelihood of confusion refusal), the specific descriptive element at issue (in a descriptiveness refusal), or the specific provision that applies. That information tells you how strong the grounds are and whether the response has a realistic chance of succeeding.
Start with a free assessment of your office action with Trama.